This book deals with combinatorial aspects of epistasis, a notion that existed for years in genetics and appeared in the ?eld of evolutionary algorithms in the early 1990s. Even thoughthe?rst chapterputsepistasisintheperspective ofevolutionary algorithms and arti?cial intelligence, and applications occasionally pop up in other chapters, thisbookisessentiallyaboutmathematics, aboutcombinatorialtechniques to compute in an e?cient and mathematically elegant way what will be de?ned as normalized epistasis. Some of the material in this book ?nds its origin in the PhD theses of Hugo Van Hove  and Dominique Suys . The sixth chapter also contains material that appeared in the dissertation of Luk Schoofs . Together with that of M. Teresa Iglesias , these dissertations form the backbone of a decade of mathematical ventures in the world of epistasis. The authors wish to acknowledge support from the Flemish Fund of Scienti?c - search (FWO-Vlaanderen) and of the Xunta de Galicia. They also wish to explicitly mentiontheintellectualandmoralsupporttheyreceivedthroughoutthepreparation of this work from their family and their colleagues Emilio Villanueva, Jose Mar'a Barja and Arnold Beckelheimer, as well as our local T T Xpert Jan Adriaenssens.
This book shows how the Bayesian Approach (BA) improves wellÂ known heuristics by randomizing and optimizing their parameters. That is the Bayesian Heuristic Approach (BHA). The ten in-depth examples are designed to teach Operations Research using Internet. Each example is a simple representation of some imporÂ tant family of real-life problems. The accompanying software can be run by remote Internet users. The supporting web-sites include software for Java, C++, and other lanÂ guages. A theoretical setting is described in which one can discuss a Bayesian adaptive choice of heuristics for discrete and global optimization probÂ lems. The techniques are evaluated in the spirit of the average rather than the worst case analysis. In this context, "heuristics" are understood to be an expert opinion defining how to solve a family of problems of disÂ crete or global optimization. The term "Bayesian Heuristic Approach" means that one defines a set of heuristics and fixes some prior distribuÂ tion on the results obtained. By applying BHA one is looking for the heuristic that reduces the average deviation from the global optimum. The theoretical discussions serve as an introduction to examples that are the main part of the book. All the examples are interconnected. DifÂ ferent examples illustrate different points of the general subject. HowÂ ever, one can consider each example separately, too.
Significant research activities have taken place in the areas of local and global optimization in the last two decades. Many new theoretical, computational, algorithmic, and software contributions have resulted. It has been realized that despite these numerous contributions, there does not exist a systematic forum for thorough experimental computational testing and. evaluation of the proposed optimization algorithms and their implementations. Well-designed nonconvex optimization test problems are of major impor tance for academic and industrial researchers interested in algorithmic and software development. It is remarkable that eventhough nonconvex models dominate all the important application areas in engineering and applied sci ences, there is only a limited dass of reported representative test problems. This book reflects our long term efforts in designing a benchmark database and it is motivated primarily from the need for nonconvex optimization test problems. The present collection of benchmarks indudes test problems from literature studies and a large dass of applications that arise in several branches of engineering and applied science."
In The Search for a Relational Home, Chris Jaenicke gives the reader an inside view of what actually happens in psychotherapy and how change occurs. He describes how both participants - the patient and the therapist - feel, and how they affect each other. The reader is encouraged to vicariously partake in the process from the perspective of his or her own life experiences.
The book describes the nature of therapeutic action through a radicalized version of intersubjective systems theory. It demonstrates how psychotherapy is an outcome of a highly personal encounter between two unique human beings, and how, while the goal of psychoanalysis is to help the patient, this can only be achieved inasmuch as both participants are willing to undergo transformation. Jaenicke clarifies how both successes and failures as well as personal strengths and weaknesses play a constitutive part in the psychotherapeutic process. The Search for a Relational Home also provides theoretical and practical guidelines for supervision.
Jaenicke presents here a unique approach to the process of psychotherapy which will be vital reading for psychoanalysts, psychotherapists and those in training as well as students in all fields of mental health.
GET FIT BY USING WHAT WORKS Fitness should not be viewed as a quick fad that you can achieve and then have forever. It is a lifestyle that needs to be maintained regularly. If you truly want to become a more fit person, it will not be an easy road, but I can promise it will be worthwhile. Here is a preview of what will be covered * I will dissect the conventional definition of fitness and completely reconstruct it. * You will learn all about the 8 primary aspects of fitness that you can improve upon to become a healthy and happier person, diet, sleep, flexibility, cardiovascular training, core, functional strength, sex and mental acuity. * Healthy food selections * Various effective, well-structured workouts * The science behind why working out makes you happier *Injury prevention * Tons of useful tips and tricks for achieving and maintaining a high fitness level * How to sleep better * Increase your Libido (Sex drive) * Maintaining a high level of personal motivation * Highly effective and underutilized workout equipment i.e. Kettle bell, battle ropes, skipping ropes, rowing machine etc. I'm not writing this in an attempt to stroke my ego; I'm just an average guy who likes to feel good as often as possible. I got into fitness at a young age in the sport of flat-water kayaking. I experienced national and international success in the sport during the seven years that I competed. Fitness is something that will forever be ingrained in me and this book and my is my attempt to share my lifestyle with you. Join me on this quest for personal optimization, embrace the tremendous depth of the word fitness and allow me to show you how extensive this word actually is. Do you want to feel better, lose weight, be stronger and enjoy life to the fullest?